Most Common Use
- formation of (E)-alkenes from phosphonate esters and aldehydes or ketones
FGT: aldehyde/ketone ➛ alkene
TYPE: coupling
REGIOCHEM: none
STEREOCHEM: E (major product)
Several factors contribute to the stereochemical outcome of the HWE reaction. When resonance-stabilized phosphonate ester carbanions are used, the (E)-alkene is typically the major product.